N6-Substituted adenosine receptor agonists: potential antihypertensive agents

…, CJ Blankley, JA Bristol, HW Hamilton…

Index: Trivedi, B. K.; Blankley, C. J.; Bristol, J. A.; Hamilton, H. W.; Patt, W. C.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1043 - 1049

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Citation Number: 27

Abstract

Adenosine is known to exert a wide range of pharmacological effects including hypotension. This effect of adenosine suggested that modified analogues of adenosine might provide useful antihypertensive agents. Thus, we prepared a series of novel NB- benzocycloalkyladenosines and studied their receptor binding and antihypertensive activity. The structure-activity relationship study shows that the adenosine analogues having the ...