The Journal of Organic Chemistry

Synthesis of sugars by aldolase-catalyzed condensation reactions

CH Wong, GM Whitesides

Index: Wong, Chi-Huey; Whitesides, George M. Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3199 - 3205

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Citation Number: 125

Abstract

Dihydroxyacetone phosphate was prepared in 200-mmol scale from dihydroxyacetone by two procedures: reaction with phosphorus oxytrichloride and glycerol kinase catalyzed phosphorylation using ATP with in situ regeneration of ATP by phosphoenolpyruvate or acetyl phosphate. Dihydroxyacetone phosphate was converted to fructose 6-phosphate in 80% yield by exposure to a mixture of co-immobilized triosephosphate isomerase and ...