Discovery of potent and orally bioavailable heterocycle-based cannabinoid CB1 receptor agonists

T Kiyoi, JM Adam, JK Clark, K Davies…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 6 p. 1748 - 1753

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Citation Number: 5

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... a Department of Chemistry, Merck Research ... 3 Sativex™, 4 a medicinal cannabis extract containing a mixture of Δ 9 -THC and cannabidiol, has been recently launched for treatment of multiple sclerosis (MS)- and cancer-associated ...