A Heterobimetallic Ni/La??salan Complex for Catalytic Asymmetric Decarboxylative 1, 4??Addition of Malonic Acid Half??Thioester

M Furutachi, S Mouri, S Matsunaga…

Index: Furutachi, Makoto; Mouri, Shinsuke; Matsunaga, Shigeki; Shibasaki, Masakatsu Chemistry - An Asian Journal, 2010 , vol. 5, # 11 p. 2351 - 2354

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Citation Number: 40

Abstract

Thioesters are synthetically versatile building blocks that can be transformed to aldehydes, ketones, amides, and other functional groups under mild reaction conditions.[1] The use of malonic acid half-thioesters (MAHTs) as thioester enolate equivalents is an attractive method to mimic the biosynthesis of fatty acids and polyketides.[2–5] A highly enantioselective catalytic asymmetric decarboxylative aldol reaction of MAHT using a Cu/ ...

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