ChemBioChem

A Single PLP??Dependent Enzyme PctV Catalyzes the Transformation of 3??Dehydroshikimate into 3??Aminobenzoate in the Biosynthesis of Pactamycin

A Hirayama, T Eguchi, F Kudo

Index: Hirayama, Akane; Eguchi, Tadashi; Kudo, Fumitaka ChemBioChem, 2013 , vol. 14, # 10 p. 1198 - 1203

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Citation Number: 8

Abstract

A variety of different aminobenzoates have been identified as characteristic building blocks for the construction of structurally unique and biologically important natural products.[1] In this structural class, 2-aminobenzoate (anthranilate) and 4-aminobenzoate (p- aminobenzoate, PABA) are well-known compounds that are derived from chorismate, which is a key intermediate in the biosynthesis of the aromatic amino acids L-phenylalanine and ...