Catalysis Communications

Kinetic resolution of (R, S)-2, 2-dimethylcyclopropanecarboxamide by Delftia tsuruhatensis ZJB-05174: Role of organic cosolvent in reaction medium

RC Zheng, YS Wang, YG Zheng, YC Shen

Index: Zheng, Ren-Chao; Wang, Yuan-Shan; Zheng, Yu-Guo; Shen, Yin-Chu Catalysis Communications, 2012 , vol. 18, p. 68 - 71

Full Text: HTML

Citation Number: 7

Abstract

Both enantioselectivity and catalytic activity were greatly enhanced in Delftia tsuruhatensis ZJB-05174 catalyzed kinetic resolution of 2, 2-dimethlycyclopropanecarboxamide in the presence of ethanol and acetonitrile. The enantiomeric ratio (E) rose from 27 to 140 and 90 by addition of 5% acetonitrile and ethanol, respectively. In the scaled-up biotransformation, the reaction time was shortened to 1.33 h with an ees of 99% and 12.4 g of optically pure ...

Related Articles:

Inhibition of the mammalian. beta.-lactamase renal dipeptidase (dehydropeptidase-I) by Z-2-(acylamino)-3-substituted-propenoic acids

[Graham, Donald W.; Ashton, Wallace T.; Barash, Louis; Brown, Jeannette E.; Brown, Ronald D.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 1074 - 1090]

Regioselective ring cleavage of chiral β-trichloromethyl-β-propiolactone with organoaluminum compounds for the synthesis of optically active intermediates

[Fujisawa, Tamotsu; Ito, Takatoshi; Nishiura, Shin; Shimizu, Makoto Tetrahedron Letters, 1998 , vol. 39, # 52 p. 9735 - 9738]

Inhibition of the mammalian. beta.-lactamase renal dipeptidase (dehydropeptidase-I) by Z-2-(acylamino)-3-substituted-propenoic acids

[Journal of Medicinal Chemistry, , vol. 30, # 6 p. 1074 - 1090]

Regioselective ring cleavage of chiral β-trichloromethyl-β-propiolactone with organoaluminum compounds for the synthesis of optically active intermediates

[Tetrahedron Letters, , vol. 39, # 52 p. 9735 - 9738]

More Articles...