Synthesis

A facile synthesis of N-acetylneuraminic acid glycal

NY Kulikova, AM Shpirt, LO Kononov

Index: Kulikova, Nadezhda Yu.; Shpirt, Anna M.; Kononov, Leonid O. Synthesis, 2006 , # 24 p. 4113 - 4114

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Citation Number: 7

Abstract

Abstract Treatment of the readily available peracetylated N-acetylneuraminic acid glycosyl chloride [methyl 5-acetamido-4, 7, 8, 9-tetra-O-acetyl-2-chloro-2, 3, 5-trideoxy-β-d-glycero-d- galactononulopyranosonate)] with anhydrous Na 2 HPO 4 in refluxing MeCN quantitatively affords the peracetylated N-acetylneuraminic acid glycal [methyl 5-acetamido-4, 7, 8, 9-tetra- O-acetyl-3, 5-dideoxy-2, 6-anhydro-d-glycero-d-galacto-non-2-enonate], which can be ...

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