Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogs

MC Wani, PE Ronman, JT Lindley…

Index: Wani; Ronman; Lindley; Wall Journal of Medicinal Chemistry, 1980 , vol. 23, # 5 p. 554 - 560

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Citation Number: 379

Abstract

Camptothecin Analogues parameters for biological activity, we have continued our work on the synthesis of camptothecin analogues. This report describes the synthesis of several analogues from the key tricyclic intermediates 15a and 15b. It also describes the biological activity of these analogues and of some new water-soluble analogues. Chemistry. The synthesis of the key tricyclic intermediate 15a is shown in Scheme I. This synthetic ...