Superacid activated condensation of parabanic acid and derivatives with arenes. A new synthesis of phenytoin and 5, 5-diarylhydantoins
DA Klumpp, KY Yeung, GKS Prakash, GA Olah
Index: Klumpp, Douglas A.; Yeung, Ka Yeun; Prakash, G. K. Surya; Olah, George A. Synlett, 1998 , # 8 p. 918 - 920
Full Text: HTML
Citation Number: 21
Abstract
Abstract: A new synthetic route to phenytoin and 5, 5-diarylhydantoins is reported. Parabanic acid is converted to the 5, 5-diarylhydantoins (65-98% yield) from CF3SO3H and arenes. Deuterium substituted products are prepared in high yield from parabanic acid, CF3SO3D, and deuterated arenes.
Related Articles:
[Modutlwa, Nkaelang; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 11-12 p. 686 - 692]
Comparative study on the para-metabolic oxidation of phenytoin and decadeuteriophenytoin.
[Arzneimittel-Forschung/Drug Research, , vol. 40, # 10 p. 1076 - 1078]