Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols

…, JL Ye, T Huang, YP Ruan, J Fu, PQ Huang

Index: Chen, Bi-Shuang; Yang, Long-He; Ye, Jian-Liang; Huang, Tao; Ruan, Yuan-Ping; Fu, Jin; Huang, Pei-Qiang European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5480 - 5486

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Citation Number: 20

Abstract

An improved four-step approach for the stereoselective synthesis of long-chain anti-2-amino- 3-alkanols is described. Using this method, the syntheses of antiproliferative (antitumoral) compounds, spisulosine (ES-285, 2), clavaminols A and B (3 and 4), the deacetylated products of clavaminols H and N (7 and 8), as well as (2S, 3R)-2-aminododecan-3-ol (9) and xestoaminol C (10), have been achieved in excellent diastereoselectivities. In vitro study ...