Cholecystokinin B antagonists. Synthesis and quantitative structure-activity relationships of a series of C-terminal analogues of CI-988

…, BD Roth, BK Trivedi, D Hill, N Suman-Chauhan…

Index: Augelli-Szafran, Corinne E.; Horwell, David C.; Kneen, Clare; Ortwine, Daniel F.; Pritchard, Martyn C.; Purchase, Terri S.; Roth, Bruce D.; Trivedi, Bharat K.; Hill, David; Suman-Chauhan, Nirmala; Webdale, Louise Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 10 p. 1733 - 1745

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Citation Number: 12

Abstract

A study of structure-activity relationships of a series of 'dipeptoid'CCK-B receptor antagonists was performed in which variations of the phenyl ring were examined while the [(2- adamantyloxy) carbonyl]-α-methyl-R)-tryptophan moiety of the potent antagonist CI-988 was kept constant. Since the main focus of this study was phenyl substituent variation, series design techniques were employed to insure an adequate spread of physicochemical ...