Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral …

S Venkatraman, F Velazquez, S Gavalas, W Wu…

Index: Bioorganic and Medicinal Chemistry, , vol. 22, # 1 p. 447 - 458

Full Text: HTML

Citation Number: 3

Abstract

... Bioorganic & Medicinal Chemistry. ... Treatment of alcohol 21 with methanesulfonyl chloride and triethylamine resulted in formation of benzylic chloride 22 which was converted to the indazole analog 24 using chemistry previously described. ...

Related Articles:

Application of the Ugi four-component condensation reaction for the synthesis of α, α-and α, β-dipeptides substituted with fluoroarylalkyl pendent groups

[Shibata, Norio; Das, Biplab Kumar; Takeuchi, Yoshio Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 24 p. 4234 - 4236]

More Articles...