First Desymmetrization of 1, 3-Propanediamine Derivatives in Organic Solvent. Development of a New Route for the Preparation of Optically Active Amines §

E Busto, V Gotor-Fernandez, J Montejo-Bernardo…

Index: Bustos, Eduardo; Gotor-Fernandez, Vicente; Montejo-Bernardo, Jose; Garcia-Granda, Santiago; Gotor, Vicente Organic Letters, 2007 , vol. 9, # 21 p. 4203 - 4206

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Citation Number: 25

Abstract

The chemical synthesis and enzymatic desymmetrization of a panel of prochiral diamines have been successfully described for the first time using lipases in organic solvents. A family of 2-aryl-1, 3-propanediamines has been obtained with high enantiopurity and good yields in the PSL-catalyzed reaction using diallyl carbonate in 1, 4-dioxane.