Stereoselective chemoenzymatic synthesis of both enantiomers of protected 4-amino-2-pentanone

…, S Ciblat, JL Canet, Y Troin, H Veschambre

Index: Besse, Pascale; Ciblat, Stephane; Canet, Jean-Louis; Troin, Yves; Veschambre, Henri Tetrahedron Asymmetry, 1999 , vol. 10, # 11 p. 2213 - 2224

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Citation Number: 26

Abstract

Previously,[1]some of us have reported on a stereoselective synthesis of (2,4)-di- or (2,3,4)-trisubstituted piperidines, by an intramolecular cyclisation of chiral dienal iron tricarbonyl complexes and an achiral amine. The stereoselectivity of the reaction arose from the chirality of the organometallic complexes used and, consequently, chiral organometallic complexes had to be prepared. Another strategy to affect this cyclisation would consist of starting from a chiral amine and an ...

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