Synthesis of chirally pure 2, 5??disubstituted diketopiperazines derived from trisubstituted phenylalanines

SN Danthi, RA Hill

Index: Danthi, Satyavijayan Narasimhan; Hill, Ronald A. Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 3 p. 835 - 844

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Citation Number: 9

Abstract

Abstract Some new chirally pure 2, 5-substituted diketopiperazines were synthesized starting from 2-methoxybenzyl alcohol. This multistep synthesis proceeds through the enzymatic synthesis of chirally pure amino acids, protection and dipeptide coupling, cyclization of dipeptide ester formates, and nitration of the resulting diketopiperazines.