Homochiral (R)-and (S)-1-heteroaryl-and 1-aryl-2-propanols via microbial redox

M Fogagnolo, PP Giovannini, A Guerrini, A Medici…

Index: Fogagnolo, Marco; Giovannini, Pier Paolo; Guerrini, Alessandra; Medici, Alessandro; Pedrini, Paola; Colombi, Nicola Tetrahedron Asymmetry, 1998 , vol. 9, # 13 p. 2317 - 2327

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Citation Number: 30

Abstract

Preparation of various heteroaryl propanols 2a–g and of the corresponding propanones 3a– g as starting materials for microbial redox is described. The kinetic resolution of the racemic propanols 2a–g is obtained via oxidation with Pseudomonas paucimobilis and Bacillus stearothermophilus [(R)-alcohols, ee 74–100%]. Similar results are achieved with 3-(2- hydroxypropyl) trifluoromethylbenzene 7 (44%, ee 100% of the (R)-alcohol 6). The ...