Metal??Bearing and Trifluoromethyl??Substituted Pyrimidines: Generation and Functionalization

M Schlosser, O Lefebvre, L Ondi

Index: Schlosser, Manfred; Lefebvre, Olivier; Ondi, Levente European Journal of Organic Chemistry, 2006 , # 6 p. 1593 - 1598

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Citation Number: 15

Abstract

Abstract 5-Pyrimidyllithium species are fairly stable when the metal is flanked by two electron-withdrawing substituents such as trifluoromethyl and chlorine or bromine. Thus, the corresponding 5-carboxylic acids are produced in high yields from 4, 5-dibromo-6- (trifluoromethyl) pyrimidine and 5-bromo-4-chloro-6-(trifluoromethyl) pyrimidine upon halogen/metal permutation accomplished with isopropylmagnesium chloride or ...