Identification of (R)-1-(5-tert-butyl-2, 3-dihydro-1 H-inden-1-yl)-3-(1 H-indazol-4-yl) urea (ABT-102) as a potent TRPV1 antagonist for pain management

A Gomtsyan, EK Bayburt, RG Schmidt…

Index: Journal of Medicinal Chemistry, , vol. 51, # 3 p. 392 - 395

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Citation Number: 72

Abstract

... Journal of Medicinal Chemistry. ... heat. Blockade of TRPV1 activation by selective antagonists is under investigation by several pharmaceutical companies in an effort to identify novel agents for pain management. Here ...