Probing the Helical Secondary Structure of Short??Chain β??Peptides

D Seebach, PE Ciceri, M Overhand, B Jaun…

Index: Seebach, Dieter; Ciceri, Paola E.; Overhand, Mark; Jaun, Bernhard; Rigo, Dario; Oberer, Lukas; Hommel, Ulrich; Amstutz, Rene; Widmer, Hans Helvetica Chimica Acta, 1996 , vol. 79, # 8 p. 2043 - 2066

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Citation Number: 366

Abstract

Abstract Structural prerequisites for the stability of the 3 1 helix of β-peptides can be defined from inspection of models (Figs. 1 and 2): lateral non-H-substituents in 2-and 3-position on the 3-amino-acid residues of the helix are allowed, axial ones are forbidden. To be able to test this prediction, we synthesized a series of heptapeptide derivatives Boc-(β-HVal-β-HAla- β-HLeu-Xaa-β-HVal-β-HAla-β-HLeu)-OMe 13–22 (Xaa= α-or β-amino-acid residue) and a ...

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