Stereospecific synthesis of sugar-1-phosphates and their conversion to sugar nucleotides

SC Timmons, DL Jakeman

Index: Timmons, Shannon C.; Jakeman, David L. Carbohydrate Research, 2008 , vol. 343, # 5 p. 865 - 874

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Citation Number: 28

Abstract

As Leloir glycosyltransferases are increasingly being used to prepare oligosaccharides, glycoconjugates, and glycosylated natural products, efficient access to stereopure sugar nucleotide donor substrates is required. Herein, the rapid synthesis and purification of eight sugar nucleotides is described by a facile 30min activation of nucleoside 5′- monophosphates bearing purine and pyrimidine bases with trifluoroacetic anhydride and ...