Total Synthesis and Biological Evaluation of the Cytotoxic Resin Glycosides Ipomoeassin A–F and Analogues

…, V Hickmann, E Moulin, J Herrmann…

Index: Nagano, Takashi; Pospisil, Jiri; Chollet, Guillaume; Schulthoff, Saskia; Hickmann, Volker; Moulin, Emilie; Herrmann, Jennifer; Mueller, Rolf; Fuerstner, Alois Chemistry - A European Journal, 2009 , vol. 15, # 38 p. 9697 - 9706

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Citation Number: 26

Abstract

Abstract A multitasking C-silylation strategy using the readily available compound 26 as a surrogate for cinnamic acid represents the key design element of a total synthesis of all known members of the ipomoeassin family of resin glyosides. This protecting group maneuver allows the unsaturated acids decorating the glucose subunit of the targets to be attached at an early phase of the synthesis, prevents their participation in the ruthenium- ...

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