Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-amino-1-pyrrolidinyl) …

JP Sanchez, JM Domagala, CL Heifetz…

Index: Sanchez; Domagala; Heifetz; Priebe; Sesnie; Trehan Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1764 - 1773

Full Text: HTML

Citation Number: 43

Abstract

A series of amino acid prodrugs of racemic and chiral7-(3-amin~ l-pyrrolidinyl)-6-fluor~ l,~ naphthyridine3-~ carboxylic acids, l-cyclopropyl-6, 8difuoro-3-quinolinecarboxylic acids, l- cyclopropyl-6-fluoro-3-quinoline~ boxylic acids, and 5-amino-l-cyclopropyl-6, &difluoro-3- quinolinecarboxylic acids have been prepared and evaluated for comparative antibacterial activity. Compounds were prepared by acylation of the 3-amho group of the pyrrolidine ...