Tetrahedron

Chemoenzymatic preparation of optically active trans-and cis-cyclohex-4-ene-1, 2-diamine and trans-6-aminocyclohex-3-enol derivatives

FJ Quijada, F Rebolledo, V Gotor

Index: Quijada, F. Javier; Rebolledo, Francisca; Gotor, Vicente Tetrahedron, 2012 , vol. 68, # 37 p. 7670 - 7674

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Citation Number: 5

Abstract

Lipase from Burkholderia cepacia (PSL-C) effectively catalyzed the kinetic resolution of both racemic trans-N, N-diallylcyclohex-4-ene-1, 2-diamine (±)-6 and its precursor trans-6- (diallylamino) cyclohex-3-enol (±)-5. The resulting optically active vicinal diamine and β- amino alcohol were converted into a precursor of oseltamivir and a cis-cyclohex-4-ene-1, 2- diamine derivative, respectively.

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