A Cleavable Linker Based on the Levulinoyl Ester for Activity??Based Protein Profiling
…, BI Florea, N Li, MD Witte, J Verasdonck…
Index: Geurink, Paul P.; Florea, Bogdan I.; Li, Nan; Witte, Martin D.; Verasdonck, Joeri; Kuo, Chi-Lin; Van Der Marel, Gijs A.; Overkleeft, Herman S. Angewandte Chemie - International Edition, 2010 , vol. 49, # 38 p. 6802 - 6805
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Citation Number: 30
Abstract
Activity-based protein profiling has recently come to the fore as an attractive strategy to disclose enzyme activity in the context of complex biological samples.[1] An activity-based profiling probe (ABP) normally consists of a recognition element targeted at a specific enzyme (family), and is equipped with a reactive group through which the targeted enzymes are covalently and irreversibly modified.[2, 3] A third essential element of ABPs is the ...
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