Total synthesis of L-659,699, a novel inhibitor of cholesterol biosynthesis
…, JV Heck, JC Chabala, MN Chang
Index: Chiang; Yang; Heck; Chabala; Chang Journal of Organic Chemistry, 1989 , vol. 54, # 24 p. 5708 - 5712
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Citation Number: 26
Abstract
18 2-butenoate with activated zinc dust in refluxing THF gave 19 (a mixture of four isomers) in 44% yield along with 32% of the &lactone 20. Dehydration of 19 with thionyl chloride in the presence of pyridine in refluxing CH2C12 afforded 21 (30%) and other isomers. The protected compound 21 was converted to the target compound, L-659,699, by de-
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