A significant improvement of the efficacy of radical oxidant probes by the kinetic isotope effect

K Kundu, SF Knight, S Lee, WR Taylor…

Index: Kundu, Kousik; Knight, Sarah F.; Lee, Seungjun; Taylor, W. Robert; Murthy, Niren Angewandte Chemie - International Edition, 2010 , vol. 49, # 35 p. 6134 - 6138

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Citation Number: 32

Abstract

The accurate and sensitive detection of radical oxidants is a central problem in the field of chemical biology.[1] Radical oxidants can be detected in vitro with fluorescent leucodyes such as dihydroethidium (DHE),[2] dihydrorhodamine (DHR),[3] the hydrocyanines,[4] redoxfluor-1,[5a] and their organelle-specific analogues.[5b] Although these probes are widely used in cell culture, their accuracy is compromised by their high levels of ...