Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors

…, A Bisi, S Gobbi, M Bartolini, A Cavalli, P Valenti…

Index: Belluti, Federica; Piazzi, Lorna; Bisi, Alessandra; Gobbi, Silvia; Bartolini, Manuela; Cavalli, Andrea; Valenti, Piero; Rampa, Angela European Journal of Medicinal Chemistry, 2009 , vol. 44, # 3 p. 1341 - 1348

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Citation Number: 30

Abstract

Starting from a structure-based drug design, new acetylcholinesterase inhibitors were designed and synthesized as analogues of donepezil. The compounds were composed by an aromatic function and a tertiary amino moiety connected by a suitable spacer. In particular, the benzophenone nucleus and the N, N-benzylmethylamine function were selected. The easily accessible three-step synthesis of these compounds resulted to be ...