Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5′, 5′ bridge containing methylenebis (phosphonate) modification

AM Rydzik, M Lukaszewicz, J Zuberek…

Index: Organic and Biomolecular Chemistry, , vol. 7, # 22 p. 4763 - 4776

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Citation Number: 25

Abstract

... Chem., 2009, 7, 4763-4776 Show Compounds Show Chemical Terms Show Biomedical Terms. ... 22 The methylene group precludes any enzymatic cleavage due to the extreme stability of P–C bonds ... 23 The analogs obtained, m 7 GpCH 2 ppG, m 2 7,3′-O GppCH 2 pG, and m 2 ...