Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl] methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and …

…, D Rattendi, L Kucera, N Iyer, R Bernacki…

Index: Marasco Jr., Canio J.; Kramer, Debora L.; Miller, John; Porter, Carl W.; Bacchi, Cyrus J.; Rattendi, Donna; Kucera, Louis; Iyer, Nathan; Bernacki, Ralph; Pera, Paula; Sufrin, Janice R. Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5112 - 5122

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Citation Number: 24

Abstract

A well-defined series of 5'-([(Z)-4-amino-2-butenyl] methylamino)-5'-deoxyadenosine analogues was designed and synthesized in order to further ascertain the optimal structural requirements for S-adenosylmethionine decarboxylase inhibition and potentially to augment and perhaps separate their antiproliferative and antitrypanosomal activities. Most structural modifications had a deleterious affect on both the antitrypanosomal and antineoplastic ...