Preparation of N-protected α-amino alcohols by acetoxyborohydride reduction of N-protected α-amino acid esters

M Souček, J Urban, D Šaman

Index: Soucek, Milan; Urban, Jan; Saman, David Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 3 p. 761 - 765

Full Text: HTML

Citation Number: 17

Abstract

Abstract N-Protected α-amino alcohols were prepared by reduction of N-protected α-amino acid esters by sodium acetoxyborohydride in dioxane at elevated temperature. The reductions proceed with excellent yields and without racemisation. Reduction of the carbamate protecting groups was not observed.