Chemical communications

Activity-based high-throughput profiling of metalloprotease inhibitors using small molecule microarrays

J Wang, M Uttamchandani, LP Sun…

Index: Wang, Jun; Uttamchandani, Mahesh; Li, Ping Sun; Yao, Shao Q. Chemical Communications, 2006 , # 7 p. 717 - 719

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Citation Number: 14

Abstract

We herein describe a high-throughput small molecule microarray (SMM) method that enables quick and cost-effective identification of potent inhibitors of metalloproteases in an activity-dependent manner, thereby offering a rapid means for inhibitor discovery and profiling.