Synthetic Communications

The Copper Halide-Catalyzed Mono-Substitution of Bromine in α,-dibromoalkanes by Grignard reagents. A Reinvestigation

H Andringa, J Hanekamp…

Index: Andringa, H.; Hanekamp, J.; Brandsma, L. Synthetic Communications, 1990 , vol. 20, # 15 p. 2349 - 2351

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Citation Number: 8

Abstract

Abstract α, ω-Dibromoalkanes have been converted into mono-bromides R (CH2) nBr by reaction with the Grignard compounds RMgBr in THF in the presence of 5 mol% of copper (I) bromide. In contrast to what is suggested in the original literature, this method has a limited scope.

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