Chemo-Enzymatic Synthesis and Biological Evaluation of 5, 6-Disubstituted Benzimidazole Ribo-and 2′-Deoxyribonucleosides

…, VN Charushin, AV Baranovsky, AI Miroshnikov…

Index: Konstantinova, Irina D.; Selezneva, Olga M.; Fateev, Ilja V.; Balashova, Tamara A.; Kotovskaya, Svetlana K.; Baskakova, Zoya M.; Charushin, Valery N.; Baranovsky, Alexander V.; Miroshnikov, Anatoly I.; Balzarini, Jan; Mikhailopulo, Igor A. Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-T0784-OP, p. 272 - 280

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Citation Number: 7

Abstract

Abstract A number of new 5, 6-disubstituted benzimidazoles have been prepared and their substrate properties for recombinant E. coli purine nucleoside phosphorylase (PNP; the product of the deoD gene) in the transglycosylation reaction were investigated. The heterocyclic bases showed good substrate activity for PNP and the ribo-and 2′- deoxyribonucleosides were synthesized. The predominant (OMe and OEt) or exclusive (O ...