Synthesis and selective cyclooxygenase-2 inhibitory activity of a series of novel, nitric oxide donor-containing pyrazoles

RR Ranatunge, M Augustyniak…

Index: Journal of Medicinal Chemistry, , vol. 47, # 9 p. 2180 - 2193

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Citation Number: 86

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. Pyrazole compounds have been identified as potent, selective COX-2 inhibitors with good pharmacokinetic profiles. From this knowledge base, we sought to develop COX-2 selective pyrazoles with NO-donating capabilities. ...