Synthesis and neuroleptic activity of benzamides. Cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino) benzamide and related compounds

…, M Takashima, Y Hirata, O Hasegawa…

Index: Iwanami; Takashima; Hirata; Hasegawa; Usuda Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1224 - 1230

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Citation Number: 68

Abstract

Three series of benzamides of N, N-disubstituted ethylenediamine8 (linear alkane-1, 2- diamines), 1-substituted 2-(aminomethyl) pyrrolidines, and 1-substituted 3- aminopyrrolidines (cyclic alkane-l, 2-diamiies) were designed and synthesized as potential neuroleptics. All target compounds were evaluated for their inhibitory effecta on apomorphine-induced stereotyped behavior in rats, and a good correlation between ...