Molecular modeling and synthesis of inhibitors of herpes simplex virus type 1 uracil-DNA glycosylase

…, D Ubiali, M Pregnolato, A Verri, F Focher…

Index: Sun, Hongmao; Zhi, Chengxin; Wright, George E.; Ubiali, Daniela; Pregnolato, Massimo; Verri, Annalisa; Focher, Federico; Spadari, Silvio Journal of Medicinal Chemistry, 1999 , vol. 42, # 13 p. 2344 - 2350

Full Text: HTML

Citation Number: 25

Abstract

We recently reported the properties of the first selective inhibitors of herpes simplex virus type 1 (HSV1) uracil-DNA glycosylase (UDG), an enzyme of DNA repair that has been proposed to be required for reactivation of the virus from latency. 6-(4-Octylanilino) uracil (octAU) was the most potent inhibitor among a series of 6-(4-alkylanilino) uracils, acting in the micromolar range and without effect against human UDG. A 28.5-kDa catalytic ...