Tetrahedron: Asymmetry

Synthesis of enantiopure 1-azaspiro [4.5] dec-6-en-8-ones from L-proline derivatives

F Diaba, E Ricou, J Bonjoch

Index: Diaba, Faiza; Ricou, Eva; Bonjoch, Josep Tetrahedron Asymmetry, 2006 , vol. 17, # 9 p. 1437 - 1443

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Citation Number: 15

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... An enantioselective synthesis of protected 1-azaspiro[4.5]dec-6-en-8-one derivatives was achieved using an alkylidene carbene 1,5-CH insertion reaction as the key step. ... The synthetic studies were first devoted to the synthesis of 1 using proline 3 as the starting material. Alcohol 3 was converted to ...

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