Organic letters

Synthesis of cytimidine through a one-pot copper-mediated amidation cascade

CM Serrano, RE Looper

Index: Serrano, Catherine M.; Looper, Ryan E. Organic Letters, 2011 , vol. 13, # 19 p. 5000 - 5003

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Citation Number: 6

Abstract

A concise synthesis of cytimidine was developed utilizing tandem Cu-mediated N-aryl amidations followed by global deprotection. This sequence exploits a regioselective coupling of an iodobenzamide with a halopyrimidine that allows the union of three fragments in a single synthetic manipulation and will permit the efficient and rapid diversification of the cytimidine core.