N*-N*-S* tridentate ligand system as potential antitumor agents

…, G Cristalli, P Franchetti, M Grifantini…

Index: Antonini, Ippolito; Claudi, Francesco; Cristalli, Gloria; Franchetti, Palmarisa; Grifantini, Mario; Martelli, Sante Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1181 - 1184

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Citation Number: 48

Abstract

The 2, 2'-bipyridyl-6-carbonitrile (6) was prepared by reacting 2, 2'-bipyridyll-oxide (5) with sodium cyanide and benzoyl chloride in water; 5 was synthesized by oxidizing 2, 2'-bipyridyl with H202 in AcOH (Scheme 11). This method gave a higher total yield and used fewer steps than the one described by Case. lo