Improved synthesis of three brominated analogues of the potent environmental mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone (MX)
M Lloveras, I Ramos, E Molins, A Messeguer
Index: Lloveras, Maia; Ramos, Isabel; Molins, Elies; Messeguer, Angel Tetrahedron, 2000 , vol. 56, # 21 p. 3391 - 3397
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Citation Number: 9
Abstract
The synthesis of three brominated analogues of the environmental mutagen 3-chloro-4- (dichloromethyl)-5-hydroxy-2 (5H)-furanone (MX), namely, 3-chloro-4-(bromochloromethyl)- 5-hydroxy-2 (5H)-furanone (BMX-1), 3-chloro-4-(dibromomethyl)-5-hydroxy-2 (5H)-furanone (BMX-2) and 3-bromo-4-(dibromomethyl)-5-hydroxy-2 (5H)-furanone (BMX-3), by employing a simple procedure from a common precursor, is described.
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