Optical isomers of rocastine and close analogs: synthesis and H1 antihistaminic activity of its enantiomers and their structural relationship to the classical …

…, TW Gero, LW Jaques, WJ Welstead…

Index: Sleevi, Mark C.; Cale, Albert D.; Gero, Thomas W.; Jaques, Larry W.; Welstead, William J.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1314 - 1328

Full Text: HTML

Citation Number: 24

Abstract

Four tricyclic compounds (22-25), which were prepared in the course of the synthetic work on the rocastine series proved useful in the conformational analysis of 1. Routes of thbe compounds, shown in Schemes I11 and IV, involve the intramolecular reaction of an acid chloride with a tertiary amine and can be viewed as proceeding through