Reactions of N-benzoyl isothiocyanate with anthranilic acid and methyl anthranilate

J Kaválek, M Kotyk, S El Bahaie…

Index: Kavalek, Jaromir; Kotyk, Milan; El Bahaie, Said; Sterba, Vojeslav Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 1 p. 246 - 255

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Citation Number: 7

Abstract

Abstract N-Benzoyl-N'-(2-carboxy-and 2-methoxycarbonylphenyl) thioureas have been obtained by the reaction of N-benzoyl isothiocyanate with anthranilic acid and methyl anthranilate, respectively. Kinetics of cyclization of these compounds into 2-mercapto-3, 4- dihydro-4-quinazolone have been studied in water and in methanol. In the base-catalyzed cyclization of N-benzoyl-N'-(2-carboxyphenyl) thiourea the proper cyclization is preceded ...