Synthesis

Synthesis of an Ethyl 6-Amino-3, 5-difluorosalicylate Derivative by Sequential Regioselective Directed ortho-Metalation, A Practical Synthesis of4, 5-Diamino-3, 6, 8- …

T Akama, K Ueno, H Saito, M Kasai

Index: Synthesis, , # 12 p. 1446 - 1450

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Citation Number: 3

Abstract

... h )l\c[F NHR 83% NHPW 1481 R = H_ pivaloyl chloride 15 14b: R = P|v pyrigine ... pivaloylamin0- 2-Ktetrahydropyran-2-yl)oxy)]- 4-(trimethylsilyl)benZ0ate (13): To a solution of 12 (107 g ... SYNTHESIS 1449 H20 was added, and the mixture was warmed to rt and extracted with EtOAc ...