Synthesis

Efficient Preparation of Polyfunctional Indoles via a Zinc Organometallic Variation of the Fischer Indole Synthesis

ZG Zhang, BA Haag, JS Li, P Knochel

Index: Synthesis, , # 1 p. 23 - 29

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Citation Number: 6

Abstract

... Subsequent N-alkylation of the intermediate 1p [t-BuOK (1.2 equiv), 0 ˚C, 20 min; then Cl(CH 2 ) 3 ... During the new indole synthesis, a range of sensitive functional groups such as nitro, ester, cyano, and keto groups ... s, 1 H), 7.77 (d, J = 8.4 Hz, 1 H), 7.24 (d, J = 8.4 Hz, 1 H), 2.67 (s ...