European Journal of Organic Chemistry

Total synthesis of the cyclic peptide argyrin B

SV Ley, A Priour

Index: Ley, Steven V.; Priour, Alain European Journal of Organic Chemistry, 2002 , # 23 p. 3995 - 4004

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Citation Number: 19

Abstract

Abstract The details of the total synthesis of Argyrin B, a natural product with immunosuppressive properties, are reported below. The two most unusual amino acid residues of this cyclic peptide are 4-methoxytryptophan and dehydroalanine, which were obtained by modifying known synthetic methods. The linear peptide was assembled in a most convergent fashion then cyclisation followed by generation of the sensitive ...

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