Solution conformations of helix-forming β-amino acid homooligomers

…, LA Christianson, SR Durell, SH Gellman

Index: Appella, Daniel H.; Christianson, Laurie A.; Klein, Daniel A.; Richards, Michele R.; Powell, Douglas R.; Gellman, Samuel H. Journal of the American Chemical Society, 1999 , vol. 121, # 33 p. 7574 - 7581

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Citation Number: 127

Abstract

The conformational properties of β-peptides comprised of enantiomerically pure trans-2- aminocyclohexanecarboxylic acid (ACHC) or trans-2-aminocyclopentanecarboxylic acid (ACPC) units were studied by NMR spectroscopy in organic solvents. In pyridine-d 5 solution, ACPC hexamer 1 and ACPC octamer 2 displayed well-defined helical structures characterized by a series of 12-membered hydrogen-bonded rings (“12-helix”). The ...

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