ACS combinatorial science

Cyanoacetamides (IV): versatile one-pot route to 2-quinoline-3-carboxamides

K Wang, E Herdtweck, A Dömling

Index: Wang, Kan; Herdtweck, Eberhardt; Doemling, Alexander ACS Combinatorial Science, 2012 , vol. 14, # 5 p. 316 - 322

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Citation Number: 16

Abstract

Cyanoacetic acid derivatives are the starting materials for a plethora of multicomponent reaction (MCR) scaffolds. Herein, we describe scope of a valuable general protocol for the synthesis of arrays of 2-aminoquinoline-3-carboxamides from cyanoacetamides and 2- aminobenzaldehydes or heterocyclic derivatives via a Friedländer reaction variation. In many cases, the reactions involve a very convenient work up by simple precipitation and ...