Rational Design, Discovery, and Synthesis of a Novel Series of Potent Growth Hormone Secretagogues⊥

…, M Mimura, N Ishiyama, M Hayashida…

Index: Huang; Loew; Funamizu; Mimura; Ishiyama; Hayashida; Okuno; Shimada; Okuyama; Ikegami; Nakano; Inoguchi Journal of Medicinal Chemistry, 2001 , vol. 44, # 24 p. 4082 - 4091

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Citation Number: 26

Abstract

In the joint experimental and computational efforts reported here to obtain novel chemical entities as growth hormone secretagogues (GHSs), a small database of peptides and non- peptides known to have GHS activity was used to generate and assess a 3D pharmacophore for this activity. This pharmacophore was obtained using a systematic and efficient procedure,“DistComp”, developed in our laboratory. The 3D pharmacophore ...