Preparation of 2, 6??bis (l??menthopyrzol??3??yl) pyridines and their catalytic activity for asymmetric diels alder reaction

C Kashima, S Shibata, H Yokoyama…

Index: Kashima, Choji; Shibata, Saori; Yokoyama, Hiroyo; Nishio, Takehiko Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 5 p. 773 - 782

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Citation Number: 17

Abstract

Abstract 3-Aryl-l-menthopyrazoles 1 and 2 and related compounds were prepared from l- menthone, and their enantioselective activities were discussed as chiral ligands. In this series of compounds, 2, 6-bis (2-methyl-l-menthopyrazol-3-yl) pyridine (8a), which had both structural features of 3-phenyl-l-menthopyrazole (1b) and C 2 symmetric ligand in the molecule, should form the C 2 symmetric complex in situ with Zn (OTf) 2 or Ni (ClO 4) 2• ...