Thiourea derivatives incorporating a hippuric acid moiety: Synthesis and evaluation of antibacterial and antifungal activities

…, WM Basyouni, IMI Fakhr, EW El-Gammal

Index: Abbas, Samir Y.; El-Sharief, Marwa A.M.Sh.; Basyouni, Wahid M.; Fakhr, Issa M.I.; El-Gammal, Eman W. European Journal of Medicinal Chemistry, 2013 , vol. 64, p. 111 - 120

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Citation Number: 23

Abstract

New series of thiourea derivatives incorporating a hippuric acid moiety have been synthesized through the reaction of 4-hippuric acid isothiocyanate with various nitrogen nucleophiles such as aliphatic amines, aromatic amines, sulfa drugs, aminopyrazoles, phenylhydrazine and hydrazides. The synthesized compounds were tested against bacterial and fungal strains. Most of compounds, such as 2-(4-(3-(3-bromophenyl) thioureido) ...